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(Randomized, double-blind.) See primary paper: Walker et al., Nutrients 2019

For antihypertensive drugs like ACE inhibitors (lisinopril, ramipril), only minor changes in drug levels have been noted, which are generally not clinically significant

Consequently, the animals were surgically prepared in advance of the experiment to allow direct access to the lumen of the gut from the outside via an in-dwelling stoma

By targeting the vasculature that supports white adipose tissue, it appears to interrupt some of the metabolic dysfunction associated with obesity at a fundamental level

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Some trials and reviews suggest potential benefits for: Fasting glucose Insulin resistance markers Triglycerides Total cholesterol Waist circumference Body weight, modestly That is not nothing