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However, people are paying to use it off-label, contributing to shortages as the interest in the drug has spiked on social media

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Use within 36 months

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Our finding is in agreement with a prospective study reporting that baseline TMAO positively associated with rates of eGFR decline 21 and with studies in animal models of CKD where TMAO diet supplementation increased kidney injury 44,45 and reduced eGFR

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Megalin mediates selenoprotein p uptake by kidney proximal tubule epithelial cells

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