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Delivery of copper using BBB permeable delivery agents such as diacetyl-bis (N4-methylthiosemicarbazone) (CuATSM) used to restore copper deficiency in ALS (Hilton et al., 2024), or administration of the endogenously produced neurotrophic copper binding tripeptide Glycyl-L-Histidyl-L-Lysine -copper (GHK-Cu) (Pickart et al., 2017), or else adding PBT2-Cu would be of interest for investigation

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doi: 10.1038/nm1652 209 RooksMGGarrettWS

Warnings Consult your doctor or pharmacist before use if you are pregnant or likely to become pregnant, breastfeeding, or have a predisposition to kidney stones formation or iron disorders

Dysregulated trafficking (e.g., reduced ACSL4 transport to the ER) modulates PUFA esterification and peroxidation risk (109)

How to Take GHK-Cu GHK-Cu administered subcutaneously on a daily basis for the length of the cycle, which is normally around one month