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The ensuing oxidative stress activates NF-B signaling, stimulates neuroinflammatory glial responses, and promotes P2X purinoceptor 7 (P2X7R)-mediated inflammasome assembly, thereby establishing a self-perpetuating cycle of neurodegeneration (Lee and Hyun, 2023

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The quadriceps muscles can become weakened and atrophied, dramatically reducing knee stability and accelerating knee OA progression

Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment