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These multiple functionalities have contributed to the recent efforts to target GSTs with novel small molecule therapeutics
Henjum S, Groufh-Jacobsen S, Aakre I, Gjengedal ELF, Langfjord MM, Heen E et al (2023) Thyroid function and urinary concentrations of iodine, selenium, and arsenic in vegans, lacto-ovo vegetarians and pescatarians
doi:10.1007/s13555-020-00468-7 11
this is followed by an intermediate complex formation for the substrate attachment to both the copper ions (CuA and CuB) in the catalytic pocket