From the X-ray crystal structure of model peptides (DAHK) it is known that Cu(II) ion in NTS (DAH) is equatorially coordinated by N-terminal amine, two deprotonated peptide bond nitrogens and imidazole of His-3, whereas one apical coordination site is occupied with water 35
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an amino acid lysine at position 10 was fatty-acylated via a -glutamic acid linker to palmitic acid
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Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F
Elevated LOXL2 expression in estrogen receptor-negative breast tumors is strongly associated with unfavorable outcomes, including poor prognosis, decreased overall survival, and reduced metastasis-free survival, suggesting that LOXL2 could serve as a valuable prognostic marker for metastasis in breast cancer cases