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Tirzepatide dual GIP/GLP-1 mechanism produces greater average weight loss (22.5% vs 15% to 17% for semaglutide in comparable trials) but also tends to cause more gastrointestinal side effects, particularly at higher doses

With a muscle injection, you still received your full dose, just through a different tissue route

lost 30 lbs in 1 year I started losing weight almost immediately

In some cases, healthcare providers may recommend taking an oral antihistamine before injection, though this approach should only be implemented under medical supervision

The usual move is dropping back to the dose you tolerated, giving your body more time, then trying the increase again later, or simply staying where you are if it's working

Severe hepatic impairment may influence the suitability of this medication for certain patients