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[3] These studies also suggest that DSIP could attenuate the excitatory actions of NMDA receptors, further contributing to its sleep-promoting properties

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J., and Burkhardt, J

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KPV is a tripeptide derived from the C-terminus of alpha-MSH that directly inhibits the transcription factor NF-B, a central regulator of skin inflammation

The similarities indicate that patients with HD may undergo similar changes in glutathione metabolism during the asymptomatic stage owing to the loss of BDNF-TrkB signalling, leading to striatal vulnerability