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The increase in rate coincides with a steeper diastolic depolarization potential, shortening of the action potential duration, and a shift in the leading pacemaker site, all changes previously associated with a variety of neurohumoral factors 6769 but here identified to be independent of these

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Panieri E., Buha A., Telkoparan-Akillilar P., Cevik D., Kouretas D., Veskoukis A., Skaperda Z., Tsatsakis A., Wallace D., Suzen S., et al

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Drug reactive metabolites are thought to be a major trigger of hepatotoxicity, in particular of idiosyncratic metabolic DILI