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In animal models, it upregulates the anti-apoptotic protein Bcl-2, downregulates the pro-apoptotic protein Bax, alters mitochondrial membrane permeability, and inhibits the activation of executioner caspases such as caspase-3, thereby blocking the apoptotic signaling pathway (Liang et al., 2015)

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Glutathione injections typically contain higher levels of glutathione than oral supplements

The basis for these doses is unclear

Ptgs2, positively regulated by Hif1a, contributed to cardiac ferroptosis and the inflammatory response following CME

EBioMedicine 39:239254 Li J, Csibi A, Yang S et al (2015) Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells