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Reduced thirst

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Alternatively, in rodents, a GLP1/atrial natriuretic peptide (ANP) axis exists, whereby activation of the GLP1 receptor in cardiac tissue stimulates ANP secretion to evoke renal natriuresis and reduced BP (Kim et al., 2013)

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Enteroendocrine cells (EECs), specialized neuroendocrine cells of the intestinal epithelium, mediate this postprandial gut feedback, as they sense the luminal milieu and release gut peptides that influence metabolic homeostasis, such as GLP-1 and cholecystokinin (CCK) 16