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In studies, the highest doses of Topamax led to an average of 6% weight loss over 24 weeks, which is modest compared to GLP-1 treatments

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In the 24-week treatment period in Trial 9 in pediatric patients with type 2 diabetes mellitus [see Clinical Studies (14.6)], BYDUREON-treated patients who had high titer anti-exenatide antibodies (625) appeared to have had a lower glycemic response compared to BYDUREON-treated patients who did not have anti-exenatide antibodies

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