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STEP-1: Semaglutide 2,4 mg, the standard since 2021 The STEP-1 trial (Wilding et al., NEJM 2021, PMID 33567185) randomized 1,961 overweight or obese adults (BMI 30 or BMI 27 with comorbidities) without diabetes to semaglutide 2,4 mg/week or placebo, with lifestyle interventions administered concurrently in both arms

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If nausea remains intolerable despite these interventions, your healthcare provider may recommend extending the time between dose increases, remaining at a lower dose longer, or reducing the dose

10.1016/j.brainres.2010.03.090 Brain Res