(Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females
Anti-inflammatory actions likely arise through both direct GLP-1R activation in rare cell types and indirect neural or metabolic crosstalk
Six weeks of GLP-1 infusion resulted in significant improvements in fasting (decrease of 4.3 mM glucose) and 8 h mean glucose (decrease of 5.5 mM), fasting and mean 8h free fatty acids, a reduction in HbA1c from 9.2% to 7.9%, a decrease in fructosamine from 349 uM to 282 uM, and a reduction in gastric emptying 3,4
The manufacturer bears responsibility for ensuring safety, but the FDA does not verify those claims before the product goes on sale
GLP-1 receptor agonists work by mimicking the action of endogenous incretin hormones, which are released from the gut in response to food intake
However, there are too few relevant studies on the association between GLP-1RA and endometrial cancer to confirm that GLP-1RA can inhibit the proliferation of human endometrial cancer cells, so further research is still needed in the future
