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Indeed, several studies have demonstrated that aberrant IGF signaling plays a critical role in the pathogenesis and progression of several types of cancer, including lung, breast, colon, prostate, ovary, pancreas, and thyroid ( Nevertheless, data coming from observational studies are still conflicting and inconclusive, since some authors observe an association between insulin therapy and increased cancer risk (Tseng, 2019
Lee MMY, Kristensen SL, Gerstein HC, McMurray JJV, Sattar N
10.1530/eje.0.1370643 3 AjabnoorG