semaglutide patent expiry europe opens door to GLP-1 generics in Canada Looming GLP-1 drug patent expirations

Off-label use of Ozempic carries risks including gastrointestinal adverse effects, pancreatitis, gallbladder disease, and is not recommended during pregnancy or breastfeeding

[8] There is no established direct pharmacological mechanism by which GLP-1 receptor agonists affect the menstrual cycle or reproductive hormones, and menstrual disorders are not listed as common adverse reactions in UK product information

When FDA-approved drugs exist, outsourcing companies are not legally permitted to manufacture drugs using raw materials unless there is a clear clinical need, FDA Commissioner Marty Makary comments in a press release

Key U.S

When added to the primary outcome model, meal-stimulated changes in GLP-1 at baseline (from T0 to T30) were not significantly associated with %WL at 68 weeks ( P = 0.563)

Acute kidney injury : Dehydration from gastrointestinal side effects may impair kidney function, particularly in patients with existing renal impairment