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How Food Triggers GLP-1: The Science in Plain Language GLP-1 release is triggered by three main nutrient categories, each working through different mechanisms in your gut: Dietary Fibre Soluble and fermentable fibre is fermented by gut bacteria into short-chain fatty acids (SCFAs) butyrate, propionate, acetate which directly stimulate L-cells to secrete GLP-1
These inhibitory effects of GLP-1 could be mediated by activation of vagal afferents in the distal small intestine or by hormonal effects on the NTS-DMV circuitry (123)
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The main difference is how the medication is formulated and how intense or prolonged the side effects last
