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The use of CDK-inhibiting drugs, especially CDK4 and CDK6, induces cellular senescence by inhibiting the transition of the cell from the G1 to the S phase, simultaneously inhibiting its proliferation [81]

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Heart palpitations Pallid skin Constipation, diarrhea, and gassiness Vision loss Numbness or tingling in the extremities Depression and memory loss Sore tongue Confusion and hallucinations Personality changes Reduced sensitivity to pain or pressure Often these symptoms take several months to a year to develop and recognize, however, if youre a vegan or vegetarian and feel down or fatigued, you may be B12 deficient

doi: 10.1016/j.ejim.2014.09.007 18