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doi: 10.1016/j.jsps.2023.101923 52 ZhaoWZhangXZhouZSunBGuWLiuJet al

The origin of using ln(2) as the proportionality constant can be shown by deriving the half-life from a differential equation for drug elimination

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Future RCTs should adopt the NIHNINDS Common Data Elements for DN, pre-specify subgroup analyses based on glycaemic control and medication use, and employ adaptive or platform designs to achieve adequate power while accounting for heterogeneity

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Never discontinue prescribed diabetes medications without medical supervision, as abrupt changes can lead to dangerous glucose fluctuations