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Weight regain after discontinuation of GLP-1 class medications is well-documented the STEP 1 extension trial showed that most weight lost on semaglutide was regained within a year of stopping treatment

Fischer S, Cabrera-Fuentes HA, Noll T, Preissner KT

Exploring a New Strategy When weight seems to yo-yo despite consistent effort, and obesity-related health conditions like type 2 diabetes, high blood pressure, or sleep apnea become harder to manage, it may be time to consider a more lasting approach

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is supported by NIH research grants OT2HL161847, OT2OD032581, U24TR001608 and CDC project numbers 75D301-21-P-12254 and 75D301-23-C-18264

[DOI] [PubMed] [Google Scholar] 38.Quertemont E