This regimen (shown as a 50:50 dosage ratio) is more difficult to adjust because NPH has both a 2 hour delay, limited duration of action, and a time course that gives it prandial-like properties that can result in different levels of insulin stacking when another prandial insulin is given concomitantly (see Figure 14)
Its thickest on the tongue-facing surface of the bottom row of teeth
GLP-1 receptor activation suppresses appetite by acting on hunger-regulating neurons in the hypothalamus, slows gastric emptying, and stimulates insulin secretion in a glucose-dependent manner
Given the noise in the space, what advice do you have for people trying to sift through different recommendations for GLP-1s and who just dont know what to do
Like Semaglutide, Tirzepatide was initially designed to treat type 2 diabetes by mimicking two key hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)
Specific strains can modulate GLP-1 secretion through SCFA production and gut-brain signaling
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