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Phosphorylation at Y239/Y240 site enhances STAT3-driven immunosuppressive pathways (e.g., PD-L1 expression) while repressing STAT1-mediated immune surveillance, reducing CD8+T cell infiltration 43

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In the IC-immunized group of patients, increases in Th1 and Th2 cells among the CD 4 + T cells were associated with decrease in Treg cells and increase in Tc1 and Tc17 cells among the CD 8 + T cells

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