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Oxygen consumption has long been attributed to hydroquinone auto-oxidation and the formation of H 2 O 2 and O 2 . 3,5,22

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

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Pathogenesis involves crystallization and retention of crystals within the kidneys, which is achieved either through the formation of crystalline plugs in the terminal collecting ducts blocking their openings into the renal pelvis, or formation of plaques of calcium phosphate on the renal papillary surface

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