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Patients using once-weekly semaglutide are advised to make lifestyle changes, including a reduced-calorie diet and increased physical activity, to improve the efficacy of the drug for optimal weight loss

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The study design did not have a placebo arm and in a condition such as fibromyalgia, where placebo effects are high, it is difficult to draw any firm conclusions from the results, Professor Littlejohn told Rheumatology Republic

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