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2 Preclinical evidence and mechanistic studies This section summarizes the key in vitro and in vivo findings from preclinical studies of major classes of natural metabolites from TCMs with cardioprotective effects, and discusses the key molecular targets and pathways by which these natural metabolites exert their cardioprotective effects

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Thus, the antitumor effect of oltipraz requires Nrf2 function

BPC157 exhibits broad tissue repair capacity, suggesting that its actions may not depend on cell type-specific regulation (e.g., myocytes or epithelial cells) but rather target universal injury responses

Swarnalatha G, Ram R, Neela P, Naidu MU, Dakshina Murty KV

DigestiveHealth:Relievesconstipationanddiarrhea