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After a 7-day withdrawal period, the mice demonstrated an increase in anxiety-like behaviors and a decrease in depression-like behaviors, suggesting that anxiety related to heroin relapse was predominant at this stage of withdrawal

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Histopathologically, medication-induced melanin pigmentation is characterised by the presence of melanin within the lamina propria either as free granules or within melanophages, but without melanocytic hyperplasia

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If prescribed, compounded formulations are prepared by a licensed pharmacy following an individual evaluation by a healthcare provider