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This sequence mimics that of a natural peptide, epithalamin, which is extracted from the pineal gland of bovines

Ethics declarations Conflict of interest All authors declared the absence of any financial or personal conflicts pertaining to this work

Especially, FBD3 showed nearly identical potency and efficiency as fentanyl in either cAMP inhibition or Gi recruitment assays but had very limited -arrestin recruitment activity (Figure 6b-c)

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