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Unlike real-time stability testing, forced degradation deliberately subjects the drug substance and drug product to extreme conditions to accelerate degradation and reveal potential impurity pathways

PCBs via the action of CYPs are converted into the active metabolites [94]

Nevertheless, the mean age at death for individuals born between 1985 and 1999 has been 29 years, and earlier diagnosis by newborn screening, treatment with more palatable cystine-depleting agents, and trials with gene therapy are critical current pursuits

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