Molecular mechanism of GLP-1RAs in improving sarcopenia Alleviation of insulin resistance IR is one of the core mechanisms in the pathogenesis of type 2 diabetes mellitus, which leads to decreased glucose uptake and utilization in skeletal muscle
This Gs-biased profile may contribute to sustained receptor signaling with less desensitization, though the clinical implications of signaling bias in GLP-1 therapeutics remain an area of active investigation
Studies have also explored its potential influence on hormone release, oxidative stress, and neuroprotection
[DOI] [PubMed] [Google Scholar] 30.Benton D., Donohoe R.T
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Mehine, M., Makinen, N., Heinonen, H