This review examines the main effects of GLP-1 and its analogs, GLP-1RA, on the body, with a focus on the brain mechanisms mediated by the GLP-1R, which form the basis for using these compounds to treat brain diseases and comorbidities
doi: 10.1016/j.expneurol.2019.01.016
Galawesh T, Goljameen Midhat A, Ozdan G
Studies show that people taking GLP-1-based therapy (including exenatide, liraglutide, dulaglutide, semaglutide, or tirzepatide) are four times more likely to have food stuck in their stomachs during endoscopy (13.6% versus 2.3% in non-users) [6]
The body uses several coordinated mechanisms to make this happen: Relaxation of the gastric fundus leads to increased gastric compliance Inhibition of antral contractility reduces propulsive forces Increased pyloric tone creates greater resistance to outflow [2] Research points to the vagal nerve pathway as the main route for this action
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