In the STEP 1 extension, people who stopped semaglutide regained 11.6 percentage points of body weight over 52 weeks, ending with an average net loss of 5.6% from baseline while lifestyle support continued (STEP 1 extension data)
Another study focused on 175 overweight or obese patients
Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: June 5, 2026 MOTS-C can be stacked with several other peptides, and the pairings that hold up best are the ones built on completely different biological mechanisms
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Here is how the retatrutide effect compares to other common heart rate influences that most people experience daily without concern: This table demonstrates that the retatrutide heart rate effect falls squarely within the range of everyday physiological variations that healthy hearts handle without difficulty
This is a common source of waste that catches people off guard