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Tirzepatide: Primarily used for the treatment of type 2 diabetes, with ongoing research exploring its potential in obesity management

Adults with a body mass index of 27 kg/m 2 or higher and glycated hemoglobin of 7 to 10 percent were randomly assigned to receive once-weekly, subcutaneous tirzepatide (10 or 15 mg) or placebo for 72 weeks (312, 311, and 315, respectively)

CADTH-developed search filters were applied to limit retrieval to health technology assessments, systematic reviews, meta-analyses, indirect treatment comparisons, any types of clinical trials or observational studies, or economic studies to a secondary search of the concepts semaglutide and type 2 diabetes

3 In diabetics, GLP-1 primarily enhances -cell activity and insulin sensitivity

Best GLP-1 Telehealth Programs of 2026: Compounded Semaglutide and Tirzepatide Compared Three GLP-1 telehealth programs are worth your time in 2026: ShedRx , SkinnyRx , and Bodybuilding Health+

Semaglutide is in a class of medicine called glucagon-like peptide 1 (GLP-1) receptor agonists