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In a unilateral ureteral obstruction-induced model of renal interstitial fibrosis, upregulated glycolysis in TECs and elevated lactate levels contributed to a hypoxic and acidic microenvironment that inhibited podocyte proliferation and differentiation, thereby accelerating fibrotic remodeling (Li et al., 2018)

Tiglylglycine diffuses out of the mitochondria and is eventually excreted in the urine

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Amino acid and protein modification by oxygen and nitrogen species

You can resume daily activities immediately unless advised otherwise

The overlap with obsessive-compulsive disorder and skin picking disorder has been reported