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Alefacept is a dimeric protein resulting from the fusion of the extracellular portion of human leukocyte functionassociated antigen3 bound to CD2 with the stranded and stabilized (CH2 and CH3) portions of the human immunoglobulin IgG heavy chain

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doi: 10.1016/j.jff.2023.105783 166 GohRCMaharajanMKGopinathDFangCM

However, acetylation patterns vary by cell type, histone residue, and stress paradigm, and the therapeutic specificity of HDAC inhibitors remains an important challenge for clinical translation

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