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On the left, GLP-1 binds to the GLP-1 receptor, which itself is bound to a trimeric G protein (PDB 6B3J)

Behavioral and dietary interventions for weight loss are known to improve psychological well-being, including self-esteem, body image, health-related quality of life, and mental health, suggesting weight loss with GLP-1s may have similar beneficial impacts

Importantly, exendin-4 demonstrated resistance to DPP-4 degradation, giving it a significantly longer half-life than native human GLP-1

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