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Nuclear factor erythroid-2-related factor-2 (Nrf2) is an important antioxidant regulator that promotes the HO-1, GSH, and GPx4 expression in the downstream, eliminates ROS accumulation in the liver, and reduces malondialdehyde (MDA) levels (36)

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Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brains hypothalamus ( When AMPK is more active, it may increase feelings of hunger

The encouraging results from the AWARD-7 and cardiovascular outcome trials provide hope that the GLP-1 receptor agonists will join a growing menu of agents available to tackle the burgeoning problem of CKD in type 2 diabetes

Eur Heart J 1992;13:251-5