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As sitagliptin clearly reduced DPP-4 activity and increased GLP-1 levels in mice after BMT, these findings are consistent with impairment of GLP-1 action by bone marrowderived cells

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More serious side effects, such as pancreatitis or gallbladder issues, have been observed with other GLP-1 agonists, so ongoing research is needed to determine if Retatrutide poses similar risks

Both conditions involve damage to the retina or optic nerve and can cause sudden, often lasting vision loss

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doi: 10.1210/en.2011-2170 18 BaggioLLDruckerDJ