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Melanotan-2 is a cyclic peptide with broader receptor affinity it binds MC1R (tanning), MC3R (no known effect), MC4R (appetite suppression, nausea), and MC5R (sebum production)

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(221) performed a multi-tiered study (including clinical, in vivo and in vitro research) to investigate how PCS inhibits Kupffer cell immune response and excessive inflammation

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