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On Category 2 with no current PCAC pathway

Such substrate-dependent inhibition profiles could offer distinct therapeutic advantages (Crettol et al

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Compounding pharmacies expand this further with Bi-Est formulations (estriol and estradiol combinations), customizable progesterone preparations, and testosterone or DHEA additions when clinically indicated

Furthermore, the arrangement of COP1 WD40 domains sealed by layers of organization, suggests a potential unfavourable configuration for substrate ubiquitination