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To preliminarily explore the molecular mechanisms of tirzepatide on metabolic dysfunction-associated fatty liver disease (MAFLD), liquid chromatography-mass spectrometry (LC-MS) was employed for comprehensive metabolomic, lipidomic, and proteomic analyses in MAFLD mice fed a high-fat diet (HFD)

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Current KDIGO guidelines in fact recommend that semaglutide may be used in CKD with no dose adjustment however acknowledges there is a lack of robust data in ESKD[78]

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