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In vivo treatment with fexaramine, an intestine-restricted FXR agonist, results in less weight gain, lower insulin resistance, decreased hepatic steatosis and increased beiging of adipose tissue in diet-induced obese (DIO) mice 38 , these beneficial effects being dependent on gut microbiota and BA/TGR5 signaling 39,40

Conclusion Temporary welts or itchiness following subcutaneous administration are commonly reported in research settings

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Gnandt, E

Fowler B (1997)