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Unfolded protein response and PERK kinase as a new therapeutic target in the pathogenesis of Alzheimers disease

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Inhibition of triggering receptor expressed on myeloid cells 1 (TREM1) has been shown to improve cognitive function in T2DM mice ( Animal studies have demonstrated that overexpression of triggering receptor expressed on myeloid cells 2 (TREM2) in the hippocampus can improve cognitive dysfunction caused by long-term high-fat diets (HFD)

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The two interventions operate on distinct physiological systems