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Duzel et al., 2017

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CPS1 is a key enzyme in the urea cycle and is directly related to ammonia production.CPS1 is significantly under-expressed in hepatocellular carcinoma tissues and circulating tumor cells, and its down-regulation may be associated with hypermethylation of CpG in its promoter region, which is negatively correlated with the stage and prognosis of HCC(Chen et al

It still happens from time to time, but it was my first experience with dermatographia, kind of a double tattoo