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2.1 Anti-inflammatory signaling and antioxidant effect Low-grade vascular inflammation is a central driver of atherogenesis, promoting monocyte recruitment, cytokine secretion, and plaque progression ( 2.2 Improvement of endothelial function and reduction of adhesion molecules Endothelial activation is an early biochemical event in atherosclerosis, characterized by increased expression of adhesion molecules, including Intercellular Adhesion Molecule 1 (ICAM-1), vascular Cell Adhesion Molecule 1 (VCAM-1), Monocyte Chemoattractant Protein-1 (MCP-1), and L-selectin

Insurance coverage decisions will also influence prescribing patterns

Instead, it supports natural satiety and mindful eatingmaking it easier to build sustainable habits rather than relying solely on the medication to do the work. 3

5 , e508e522 (2023)

10.2337/dc25-S009

As AFib prevalence continues to rise with an aging population, Bilchick said combining state-of-the-art ablation technologies with therapies that address metabolic and inflammatory pathways might significantly improve long-term outcomes.