They can stick in your body and not give you the vitamins you need
Endocrinology 2001
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Our take: rather than gambling on which it is, avoid triggering it in the first place
Deficiency is particularly common in elderly people, because the ability to absorb vitamin B12 can decrease with age
Conservative dosing also reduces risk of excessive energy deficit and the metabolic stress markers (low T3, menstrual irregularity) that emerge when both compounds are pushed to upper dose ranges simultaneously.