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The typical American diet contains 250 grams of carbs per day, mostly in the form of refined grains, processed meats, and other highly processed foods

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2730 In addition to direct receptor binding and neuronal activation at these sites, peripherally secreted GLP-1 also targets GPCRs on the vagus nerve, which transmit signals to the NTS via vagal afferents

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Urolithins are microbial metabolites derived from ellagitannins and ellagic acid, polyphenols naturally present in foods such as berries, pomegranate, and nuts (25)