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Recently, two mechanisms involved in the gut-brain axis have attracted increasing attention due to their role in the pathogenesis and progression of PD, namely, disruption of the composition of microorganisms living in the intestine (intestinal microbiome) and dysfunction of enteroendocrine cells, accompanied by impaired signaling through the GLP-1R [60]

But its not clear whether these outcomes were caused by the drug itself, the mothers weight loss, or other factors

22,23 The pathway diversification of insulin signaling downstream targets of Akt activation leads to different distal signaling in target tissues response to insulin (Fig

Once inside the cell, the expectation is that haem-bound iron can be liberated through enzymatic cleavage of the porphyrin ring by haem oxygenase enzymes that are present in many bacterial species (Richard et al., 2019)

In T2DM rat models, TMAO disrupts intercellular signal synchronization by interfering with connexin 43 expression and distribution in cardiomyocytes, resulting in atrial electrical conduction abnormalities and electrophysiological derangements (Jiang et al., 2022)