differences between tirzepatide and semaglutide vs. Semaglutide: What's the Difference? Tirzepatide vs Semaglutide 2026: 22%

According to the MHRA-approved Summary of Product Characteristics (SmPC), nausea is very common (affecting more than 1 in 10 people), while abdominal pain, vomiting, diarrhoea, and constipation are common (affecting between 1 in 100 and 1 in 10 people)

References Mayo Clinic

These side effects typically resolved on their own and were most common during or just after dose increases

not drinking enough fluids can make headaches and constipation worse while you adjust to Mounjaro

It may also increase low blood sugar risk when used with insulin or sulfonylureas

This is just your cycles way of adjusting to your new weight, and think of it as a temporary shake up