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The effect size for each treatment was the mean weight change (in kg) accompanied by a 95% confidence interval (CI)

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What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes

A safe and successful therapy depends on regular monitoring and suitable dosage modifications depending on particular medical conditions and coexisting drugs

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