step 10 semaglutide Once-weekly 7·2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial Once-weekly semaglutide 2·4 mg in

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When to Adjust Signals documented across clinical and community sources, framed descriptively rather than as instructions: Signs the response is on track (per community sources): first visible darkening on UV-exposed areas somewhere in weeks 2-3, deepening through week 4, then a plateau the cosmetic mirror of the day-15 clinical peak (Haylett et al., 2011)